Rocky and Bullwinkle have been living off the finances made from the reruns of their cartoon show. Boris and Natasha somehow manage to crossover into reality and team up with Fearless Leader, an evil criminal turned media mogul with some evil plans up his sleeve. Rocky and Bullwinkle must stop the three of them before they wreak havoc.
June Foray, Keith Scott, Rene Russo, Jason Alexander, Piper Perabo, Randy Quaid, Robert De Niro, Jonathan Winters, Janeane Garofalo, Carl Reiner, John Goodman, Kenan Thompson, Kel Mitchell, David Alan Grier, Drena De Niro, Lily Gibson, Jane Edith Wilson, Mark Holton, Doug Jones, Taraji P. Henson